If the trumpets and vials move in tandem, and if the Islamic State (IS) represent the locusts of the fifth trumpet; then it corresponds with the fifth vial which is darkness and gnawing tongues (a symptom of dehydration; article) over the beast's kingdom (Sunni Islam; aka Babylon).  Thus the sixth trumpet and vial would commence after the five months of locusts end.

The last five years of drought in the Middle East have beaten records over 100 years old. article
 
"12One woe is past; and, behold, there come two woes more hereafter. 13And the sixth angel sounded, and I heard a voice from the four horns of the golden altar which is before God, 14Saying to the sixth angel which had the trumpet, Loose the four angels which are bound in the great river Euphrates. 15And the four angels were loosed, which were prepared for an hour, and a day, and a month, and a year, for to slay the third part of men. 16And the number of the army of the horsemen were two hundred thousand thousand: and I heard the number of them. 17And thus I saw the horses in the vision, and them that sat on them, having breastplates of fire, and of jacinth, and brimstone: and the heads of the horses were as the heads of lions; and out of their mouths issued fire and smoke and brimstone. 18By these three was the third part of men killed, by the fire, and by the smoke, and by the brimstone, which issued out of their mouths. 19For their power is in their mouth, and in their tails: for their tails were like to serpents, and had heads, and with them they do hurt. 20And the rest of the men which were not killed by these plagues yet repented not of the works of their hands, that they should not worship devils, and idols of gold, and silver, and brass, and stone, and of wood: which neither can see, nor hear, nor walk: 21Neither repented they of their murders, nor of their sorceries, nor of their fornication, nor of their thefts." (Revelation 9:12-21)

"10And the fifth angel poured out his vial on the seat of the beast; and his kingdom was full of darkness; and they gnawed their tongues for pain, 11And blasphemed the God of heaven because of their pains and their sores, and repented not of their deeds. 12And the sixth angel poured out his vial on the great river Euphrates; and the water thereof was dried up, that the way of the kings of the east might be prepared. 13And I saw three unclean spirits like frogs come out of the mouth of the dragon, and out of the mouth of the beast, and out of the mouth of the false prophet. 14For they are the spirits of devils, working miracles, which go forth to the kings of the earth and of the whole world, to gather them to the battle of that great day of God Almighty. 15Behold, I come as a thief. Blessed is he that watches, and keeps his garments, lest he walk naked, and they see his shame. 16And he gathered them together into a place called in the Hebrew tongue Armageddon." (Revelation 16:10-16)

The sixth trumpet and the sixth vial are the only two passages in the New Testament which mention the Euphrates River.  The news portrayed the Mosul Dam on the Tigris River as very poorly built and difficult to maintain.  What if there were FOUR key dams on the Euphrates River which God graciously sent angels to protect?  Will they soon be relieved of duty so that IS can completely restrict the flow of water in order to control the people, thus enabling an army of 200,000,000 to cross it?

The IS has threatened Turkey to give them control of a dam, and IS now has 49 Turks from Mosul to bargain with. article

"Since January 2014, the Islamic State (IS) in Iraq has succeeded in taking control of several dams. To date, the group controls the Haditha Dam (the second-largest in the country), the Samarra Barrage and the Nuaimiyah Dam. Between January and April, the IS also controlled the strategic Fallujah Dam.
The dams are an essential element of the group’s military strategy. The IS has already proved its determination to use the dams as a weapon by deliberately drowning government forces around the Nuaimiyah Dam. When in control of the Fallujah Dam, the group closed eight of the ten doors of the dam, reducing water levels in the south and flooding land upstream." article

"In April 2014, fighters of the Islamic State in Iraq and Syria captured the Nuaimiyah Dam in western Iraq, despite earlier efforts to defend the site. They then overflowed it to dislodge Iraqi soldiers dug in upstream of the site—and to deny drinking water to civilians downstream." article

"The [Haditha] dam, which regulates the waters of the River Euphrates, is located north of the city of Haditha, approximately 150 miles (240 km) northwest of Baghdad. It is a major source of hydroelectricity for Iraq’s national grid behind Mosul Dam, which was recaptured by Kurdish and Iraqi forces backed by US air power on Monday." article

It would be an interesting twist if the red, yellow and blue uniformed army gathered in the Jezreel Valley was actually invited by Israel to use that area as a base from which to launch a campaign against IS.  Then if Israel launched rockets against Iran's nuclear facilities, this coalition army turned and attacked Israel instead.  There are so many ways this could play out, and several have nothing to do with prophecy.
I'm just continuing to watch for my Lord's return.

That Which Withholds Has Been Removed

"Let no man deceive you by any means: for that day shall not come, except there come a falling away first, and that man of sin be revealed, the son of perdition; Who opposes and exalts himself above all that is called God, or that is worshipped; so that he as God sits in the temple of God, showing himself that he is God. Remember you not, that, when I was yet with you, I told you these things? And now you know what withholds that he might be revealed in his time. For the mystery of iniquity does already work: only he who now lets will let, until he be taken out of the way. And then shall that Wicked be revealed." (2 Thessalonians 2:3-8a)
Barnes' Bible Commentary on this verse: "The most natural interpretation is that which refers it to civil power, meaning that there was something in the form of the existing administration which would prevent this development until that restraint should be removed."

I did not know what to expect on the first day of the Great Tribulation, and so I prayed and asked God for revelation, and I received the song, "This mountain shall be removed by My Spirit, sayeth the Lord."
"This is the word of the LORD to Zerubbabel, saying, Not by might, nor by power, but by my spirit, said the LORD of hosts. Who are you, O great mountain? before Zerubbabel you shall become a plain: and he shall bring forth the headstone thereof with shoutings, crying, Grace, grace to it." (Zechariah 4:6b-7)
The "great mountain" during Zerubbabel's time was the empire of Babylon, which is called the "destroying mountain" in Jeremiah 51:24-25. Mountains refer to empires or kingdoms. I think in order for God to accomplish what He intends to do in the Middle East, He needed to remove the United States of America. The first war the United States of America encountered after becoming a nation was with the Muslims in 1801 who had declared war on all Christian nations. They were known as the Barbary Pirates of the Mediterranean. General Eaton told the new Secretary of State, "It is a maxim of the Barbary States, that 'The Christians who would be on good terms with them must fight well or pay well.'" At first the US paid their extortion money for safe passage, but when they took the ship and imprisoned the crew which brought the money, the US marines successfully stormed the shores of Tripoli. [http://www.daddezio.com/italy/barbary/history.html]

Today, President Obama declared to the Turkey parliament, "Let me say this as clearly as I can: The United States is not, and will never be, at war with Islam." He further clarified, "Our partnership with the Muslim world is critical in rolling back a fringe ideology that people of all faiths reject." President Obama continued, "But I also want to be clear that America's relationship with the Muslim world cannot and will not be based on opposition to al Qaeda. Far from it. We seek broad engagement based upon mutual interests and mutual respect. We will listen carefully, bridge misunderstanding, and seek common ground." Each demonstration of American weakness and withdrawal emboldens the jihadists. Now with America subdued, the Antichrist may soon appear and declare himself to be god.

God's Hand ready to put those who hate Him into the Fire
There was also a unique sign in the heavens reported today. "In a new image from NASA's Chandra X-ray Observatory, high-energy X-rays emanating from the nebula around PSR B1509-58 have been colored blue to reveal a structure resembling a hand reaching for some eternal red cosmic light." [http://www.foxnews.com/story/0%2C2933%2C512767%2C00.html]
"Your hand shall find out all your enemies: your right hand shall find out those that hate you. You shall make them as a fiery oven in the time of your anger: the LORD shall swallow them up in his wrath, and the fire shall devour them. Their fruit shall you destroy from the earth, and their seed from among the children of men. For they intended evil against you: they imagined a mischievous device, which they are not able to perform. Therefore shall you make them turn their back, when you shall make ready your arrows on your strings against the face of them." (Psalms 21:8-12)
"Though I walk in the middle of trouble, you will revive me: you shall stretch forth your hand against the wrath of my enemies, and your right hand shall save me. The LORD will perfect that which concerns me: your mercy, O LORD, endures for ever: forsake not the works of your own hands." (Psalms 138:7-8)